People
Dr. Christian Willrodt
Department of Solar Materials
Helmholtz Centre for Environmental Research
Kubus, Room 214
Permoserstraße 15
04318 Leipzig
Tel.: +49-341-235 46 97
Fax.: +49-341-235 45 46 97
E-Mail:
Research Interests
- integrated catalyst and process engineering for the development of scalable microbial bioprocesses
- development of productive oxygenase-based whole-cell bioprocesses
- biocatalyst and reaction design for the microbial synthesis of challenging (volatile, hydrophobic, toxic) chemicals
- development of novel production concepts for isoprenoid biosynthesis
- metabolic and pathway engineering
CV / Scientific Career
| since 10/2015 | Postdoctoral Researcher Bioprocess Development Department Solar Materials Helmholtz Center for Environmental Research (UFZ), Leipzig |
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| 01/2014-01/2016 | Research Assistant (Dissertation) Department Solar Materials Helmholtz Center for Environmental Research (UFZ) Leipzig Supervisors: Prof. Dr. A. Schmid and Dr. Mattijs Julsing |
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| 10/2011-12/2013 | Research Assistant (Dissertation), Chair of Biotechnology, Department of Chemical and Biochemical Engineering, TU Dortmund University, Supervisors: Prof. Dr. A. Schmid and Dr. Mattijs Julsing |
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| 03/2011-09/2011 | Master Thesis, Biological and Chemical Microstructuring, Department of Chemistry and Chemical Biology, TU Dortmund University, Prof. Dr. C. M. Niemeyer, "Preparation and application of semisynthetic Protein-DNA conjugates“ | ||
| 10/2009-09/2011 | Studies, Master of Science Chemical Biology, TU Dortmund University | ||
| 07/2010-12/2010 | Visiting Scientist, Bioanalytical Microsystems and Biosensors Laboratory, Cornell University, Ithaca, NY, USA, Prof. Dr. Antje Baeumner, “Investigations Toward an Nanofiber-enhanced Microfluidic Biosensor for Pathogen Detection” | ||
| 03/2009-07/2009 | Bachelor Thesis, Chair of Biotechnology, Department of Chemical and Biochemical Engineering, TU Dortmund University, Prof. Dr. A. Schmid and Dr. Bruno Bühler, “Purification and Characterization of the Alkane Monooxygenase AlkB” | ||
| 10/2005-09/2009 | Studies, Bachelor of Science Chemical Biology, TU Dortmund University |
Publications
Peer Reviewed Articles
2017
- Willrodt C.*, Halan B.*, Karthaus L., Rehdorf J. , Julsing M. K., Bühler K. and Schmid A. (2017)
Continuous multistep synthesis of perillic acid from limonene by catalytic biofilms under segmented flow.
Biotechnology and Bioengineering, 114(2):281–290, DOI-Link
* These authors contributed equally to this work.
- Kadisch M.*, Willrodt C.*, Hillen M, Bühler B. and Schmid A. (2017)
Maximizing the stability of metabolic engineering-derived whole-cell biocatalysts.
Biotechnology Journal, 12(8):1600170, DOI-Link
* These authors contributed equally to this work.
2016
- Willrodt C., Hoschek A, Bühler B., Schmid A. and Julsing M. K. (2016)
Decoupling production from growth by magnesium sulfate limitation boosts de novo limonene production.
Biotechnology and Bioengineering, 113(6):1305-1314, DOI-Link
2015
- Willrodt C., Hoschek A, Bühler B., Schmid A. and Julsing M. K. (2015)
Coupling limonene formation and oxyfunctionalization by mixed-culture resting cell fermentation.
Biotechnology & Bioengineering, 112(9):1738-1750, DOI-Link
- Willrodt C., Karande R., Schmid A. and Julsing M. K. (2015)
Guiding efficient microbial synthesis of non-natural chemicals by physicochemical properties of reactants.
Current Opinion in Biotechnology, 35:52-62, DOI-Link
2014
- Willrodt C., David C., Cornelissen S., Bühler B., Julsing M. K. and Schmid A. (2014)
Engineering the productivity of recombinant Escherichia coli for limonene formation from glycerol in minimal media.
Biotechnology Journal, 9(8):1000–1012, DOI-Link
2011
- Schrewe M., Magnusson A., Willrodt C., Bühler B. and Schmid A. (2011)
Kinetic analysis of terminal and unactivated C-H bond oxyfunctionalization in fatty acid methyl esters by monooxygenase-based whole-cell biocatalysis.
Advanced Synthesis and Catalysis, 353:3485 – 3495, DOI-Link
Books & Bookchapters
2016
- Willrodt C. (2016)
Synthetic biology for synthetic chemistry – Microbial de novo production and selective functionalization of limonene.
Shaker Verlag GmbH, Herzogenrath, Deutschland, ISBN: 978-3-8440-4296-2
Oral Presentations
2016
- Willrodt C., Hoschek A, Bühler B., Julsing M. K. and Schmid A. (2016)
Challenging the limits of metabolic engineering: Mixed-strain resting cell rermentations ror oxygenated monoterpenoid production.
European Symposium on Biochemical Engineering Sciences (ESBES) 2016, 11th -14th of September 2016, Dublin, Ireland
Posters
2015
- Willrodt C., Hoschek A, Julsing M. K. and Schmid A. (2015)
Mixed-culture resting cell fermentation enables production of oxygenated monoterpenoids.
Bioflavour 2015 - International Conference on Flavour and Fragrance Biotechnology, 9. - 11. September 2015, Frankfurt, Germany
- Willrodt C., Hoschek A, Julsing M. K. and Schmid A. (2015)
Synthetic biology for synthetic chemistry Enabling Cascade Reactions by Modular Two-Strain Fermentations.
Gordon Research Conference on Synthetic Biology, 28. June - 3. July 2015, Newry, ME, USA
2013
- Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
Biocatalyst and process development for fermentative synthesis of monoterpene-derived natural product.
1st European Conference on Natural Products, 22. - 23. September 2013, Frankfurt am Main, Germany
- Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
Biocatalyst and process development for the fermentative synthesis of monoterpene-derived natural product.
Biotrans 2013, 21. - 25. July 2013, Manchester, United Kingdom
- Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
Preparation of monoterpenes from cheap and renewable resources.
Tag der Chemie, TU Dortmund, 1. February 2013, Dortmund, Germany
2012
- Willrodt C., Julsing M. K., Bühler B. and Schmid A. (2012)
Monoterpenoid production in metabolically engineered Escherichia coli.
Biocat 2012, 31. August - 4. September 2012, Hamburg, Germany